The NEXIUM® trial was a multicenter, randomized, open-label, fixed-term, two-period, crossover, flexible-dose study conducted by the University of Pennsylvania in Philadelphia, in the treatment of patients with chronic heart failure (CHF), with primary care use of PPIs (omeprazole and esomeprazole) as monotherapy or in combination with a lansoprazole-based medication.
Study design:A multicenter, randomized, open-label, fixed-term, two-period, crossover, flexible-dose study, including a primary care use of PPIs as monotherapy or in combination with a lansoprazole-based medication.
Primary outcome:Primary outcome measure: patients were randomized to receive NEXIUM® (esomeprazole) (either monotherapy or in combination with a lansoprazole-based medication, or with a lansoprazole-based medication) or placebo. The primary endpoints were clinical response, quality of life (QoL), and safety.
Secondary outcomes:Primary endpoint of response, quality of life, and safety were defined as adverse events, adverse events with a frequency of ≥1% and ≥5% in the NEXIUM® group, and adverse events with a frequency of ≥5% and ≥10% in the placebo group. Quality of life (QoL) was measured by the Global Burden of Disease Questionnaire (GAD-Q) (for details, see ).
Statistical analysis:At weeks 12 and 24, patients were assigned to receive NEXIUM® (esomeprazole) or placebo. For each treatment group, a baseline measurement of the composite of the following QoL: global Burden of Disease (GBD), global health-related quality of life (HR-QoL), and QoL questionnaires were assessed; the QoL was compared between the groups using one-way analysis of variance (ANOVA) with body mass index (BMI) as the within-subjects covariate.
Study population:A total of 4,731 patients were randomized to receive NEXIUM® or placebo. The primary outcome measure was the primary endpoint of the secondary endpoint of symptom improvement in the NEXIUM® group. For the primary endpoint of the secondary endpoint of quality of life, the primary endpoint of the quality of life was compared between the groups using a one-way ANOVA with BMI as within-subjects covariate.
Study hypothesis:The primary endpoint of the primary endpoint of the secondary endpoint of QoL was defined as the difference between the primary and secondary endpoints of QoL.
Intervention:Patients were randomized to receive NEXIUM® (esomeprazole) or placebo. The primary endpoint of the secondary endpoint of quality of life was defined as the difference between the primary and secondary endpoints of QoL.
Follow-up:The primary endpoint of the secondary endpoint of QoL was the difference between the primary and secondary endpoints of QoL.
Data analysis:The primary analysis of the primary endpoint of the QoL was the difference between the primary and secondary endpoints of QoL.
Results:The primary analysis of the primary and secondary analysis of the QoL was similar in the NEXIUM® and placebo groups, but the primary analysis of the QoL was not, therefore, included in the analysis.
The secondary analysis was not, therefore, included in the analysis.
The primary analysis of the QoL was not, therefore, included in the analysis.
Conclusion:The primary analysis of the primary and secondary analysis of the QoL was not, therefore, included in the analysis.
Nexium Control 20mg Tablets are designed to help you fightburns, acid regurgitations, and other acid-related regurgitation symptoms by preventing acid from reaching your stomach. Each tablet contains 20mg of Esomeprazole, and offers a 24-hour window of opportunity. This medication works for up to 7 days and is suitable for adults and children over 12. Keep this product out of reach of children.
Features:
A gastroenterologist and a pharmacist in your area have recommended Nexium 40 mg for the treatment of chronic gastric ulcer, which can be life-threatening in the presence of severe acid. In the meantime, your doctor or pharmacist will advise you of the correct dosage, and the medication may be refilled if needed. Nexium 40 mg should be taken in the morning, with or without food.
The drug may also be used to treat stomach ulcers, ulcerative colitis, or Crohn’s disease. It can be taken in combination with a high-fat meal or with a low-fat meal to reduce the risk of stomach irritation.
Your doctor may prescribe Nexium 40 mg to treat the following conditions:
• It is not recommended for use with other anticoagulants, including warfarin, as it can increase bleeding risk.
• It can cause gastrointestinal symptoms in rare cases, including heartburn, flatulence, gas, heartburn, abdominal pain, bloating, gas, diarrhea, and loss of appetite. These symptoms usually resolve on their own without treatment.
• It is not recommended for use in the elderly, patients with liver or kidney impairment, and patients with anemia (iron deficiency).
• It may interact with other medicines and foods, and increase the risk of side effects.
The following is a list of medicines that can interact with Nexium 40 mg:
• Cyclosporine (a medicine used to treat immune disorders), anticoagulant medicines, such as warfarin, or antibiotics like erythromycin, ketoconazole, itraconazole, and ritonavir, which can both increase the risk of blood clots.
• Ketoconazole and ritonavir can both increase the risk of ulcers.
• The use of Nexium 40 mg may increase the risk of gastrointestinal bleeding.
• It can increase the risk of severe allergic reactions.
• The use of Nexium 40 mg may reduce the amount of stomach acid in patients with ulcers.
• It can increase the risk of ulcer complications and bleeding.
• You should not take Nexium 40 mg if you are pregnant or breastfeeding. The effects of Nexium 40 mg on the developing baby may not be expected.
• You should not take Nexium 40 mg if you have heartburn, flatulence, heartburn, or abdominal pain. Taking Nexium 40 mg with food can increase the risk of stomach irritation.
• Taking Nexium 40 mg with other medicines such as warfarin can also decrease the risk of stomach irritation.
• You should not take Nexium 40 mg if you have a history of stomach bleeding.
• If you are taking NSAIDs (non-steroidal anti-inflammatory drugs), you should avoid taking Nexium 40 mg.
• You should not use Nexium 40 mg if you have liver disease. Nexium 40 mg may also affect your liver or increase liver enzymes. Your doctor or pharmacist may recommend a reduced dose of Nexium 40 mg for the shortest possible length of time.
• You should not use Nexium 40 mg if you have any of the following conditions:
• Kidney problems
• Asthma
• Asthma attacks
• Asthma can cause severe stomach pain.
• You should avoid taking Nexium 40 mg if you have ever had stomach ulcers.
• You should not take Nexium 40 mg if you are allergic to any of the ingredients of this medicine, or any of the other ingredients in this medicine.
• You should not take Nexium 40 mg if you have recently had a blood clot.
• You should use Nexium 40 mg with caution in people with bleeding problems such as Peyronie’s disease, or if you have had a stroke.
• You should use Nexium 40 mg with caution in patients with kidney failure.
• You should use Nexium 40 mg with caution if you have severe kidney failure.
Details
Nexium Control 40mg tablets are an antiretroviral medicine used in adults to treat reflux and heartburn. It contains ReCaptopril (Nexium) which is used in adults for adults who are at least partial height of reflux or gastro-oesophageal reflux disease (GORD) in their digestive system, and it causes a bending of the penis while urinating. If the erection persists after taking this medicine it can lead to painful penile pains. It may be taken with or without food. Before you take this medicine give the patient complete medical history and any other information they may have. Before taking this medicine take the patient complete a written prescription. Nexium Control 40mg tablets contain 3g of esomeprazole (Nexium) which is an antacid that works by stopping the acid from being broken down in your stomach. When the esophagus becomes damaged it breaks down the food in your stomach. Esomeprazole 20mg contains esomeprazole which prevents the esophagus from being broken down. In case of an esomeprazole 20mg tablet, do not take more than one tablet in any 24-hour period. It should be taken regularly for a period of at least 4 days. If necessary, the patient may have a gastro-esophageal reflux disease (GERD) or acid reflux disease (GERD with acid reflux). Do not take this medicine if you have ever had an allergic reaction to esomeprazole 20mg or any of the ingredients listed at the end of the V. R. list.
Nexium Control 40mg tablets are an antiretroviral medicine used in adults who are at least partial height of reflux or gastro-oesophageal reflux disease (GORD) or have a poor digestion. It contains ReCaptopril (Nexium) which works by stopping the acid from being broken down in your stomach. Do not take this medicine if you are allergic to esomeprazole 20mg or any of the ingredients listed at the end of the V.
Nexium Control 40mg tablets contain 3g of esomeprazole (Nexium) which works by stopping the acid from being broken down in your stomach. Do not take this medicine if you have ever had an allergic reaction to esomeprazole 20mg or the ingredients listed at the end of the V.
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View MoreShow MoreA new treatment for heartburn in adults is on the market, and it is a good option for patients who need the little purple pill they love. It's a combination of two medicines: Nexium and Prilosec. Nexium is used to treat heartburn in adults, and Prilosec is used to treat ulcers caused by certain conditions. Prilosec is available in the form of capsules, and it works by stopping the production of a substance that causes stomach upset. Nexium and Prilosec both work well for heartburn, but one must be careful with Prilosec and Nexium. Do not take Prilosec if you have a stomach condition such as heartburn, or if you have suffered a peptic ulcer or acid reflux. Prilosec and Nexium are both effective in treating ulcers caused by certain conditions. Taking them together will help prevent ulcers from returning and may also help prevent the development of chronic malignancies such as cancer of the esophagus or stomach ulcers. Nexium and Prilosec are also helpful in treating some other stomach problems. You must talk to a doctor before taking Prilosec and Nexium together if you are pregnant or breastfeeding. Prilosec and Nexium work by decreasing the amount of acid produced by the stomach. Nexium is available in capsule form and is usually taken once or twice daily with or without food. Prilosec capsules should be swallowed whole with a glass of water. Prilosec can be taken with or without food. Prilosec capsules also contain inactive ingredients, such as starch, lactose, sucrose, magnesium stearate, talc, sodium lauryl sulfate, and titanium dioxide. Prilosec may cause stomach bleeding. If you are experiencing symptoms of stomach ulcers or bleeding, such as pain, bloating, or uncomfortable after eating, talk to your doctor right away before taking Prilosec. Prilosec is only available with a prescription and may require a prescription of a different medicine. Prilosec may cause ulcers in the stomach or small intestine, which can be painful or difficult to treat with other medicines. If you are unable to take Prilosec or Nexium with other medicines, talk to your doctor before taking Prilosec or Nexium with any other medicine. Prilosec may cause ulcers in the stomach or intestine. If you have suffered a peptic ulcer or acid reflux, or if you have suffered from a heartburn, Prilosec and Nexium work best for the stomach lining. If you have suffered a heartburn, Prilosec and Nexium and stomach bleeding ulcer may be treated with other medicines, and Prilosec and Nexium and stomach bleeding ulcer may be treated with other medicines. Prilosec and Nexium can be taken with or without food. Prilosec can also cause stomach bleeding in some people. It is important to drink lots of water while taking Prilosec. Prilosec and Nexium may also cause stomach upset. If you have been told by your doctor that you have an intolerance to some sugars or trans-sulfuration products, talk to your doctor before taking them.
Nexium and Prilosec CapsuleProduct Details:
Pack Size: | Packaging: | Type of Capsule: |
Form: | Capsule: | Prescription: |
Brand: | Nexium | Generic: |
Manufacturer: | Eli Lilly & Co. |
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